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Publications
Therapeutic use of nucleotides in respiratory and ophthalmic diseases. Yerxa BR. Drug Development Research, 2001, 52:196-201.
P2Y receptors: Biological advances and therapeutic opportunities. Shaver SR. Current Opinion in Drug Discovery and Development, 2001, 4(5):665-670.
P2Y2 Receptor Agonists: Structure, Activity and Therapeutic Utility. Benjamin R. Yerxa and Fred L. Johnson. Drugs of the Future, 1999, 24:759-769.
Mucous Clearance as a Primary Innate Defense Mechanism for Mammalian Airways. Michael R. Knowles and Richard C. Boucher. The Journal of Clinical Investigation. 2002, 109:571-577.
P2Y Receptor Agonists: Role in Mucosal Hydration and Mucociliary Clearance. William Pendergast and Richard Evans. New Drugs for Asthma, Allergy and COPD. 2002, 31:165-168.
Effects of Diadenosine Polyphosphates on Tear Secretion in New Zealand White Rabbits. J. Pintor, A. Peral, C.H. V. Hoyle, C. Redick, J. Douglass, and B. Yerxa. Journal of Pharmacology and Experimental Therapeutics. 2002, 300(1):291-297.
Two Multicenter, Randomized Studies of the Efficacy and Safety of Cyclosporine Ophthalmic Emulsion in Moderate to Severe Dry Eye Disease. Kenneth Sall, Onex Dara Stevenson, Thomas K. Mundorf, Brenda L. Reis, and CsA Phase 3 Study Group. Ophthalmology. 2000, 107:631-639.
Prevalence of and Risk Factors for Dry Eye Syndrome. Scot E. Moss, Ronald Klein, and Barbara E.K. Klein. Archives of Ophthalmology. 2000, 118:1264-1268.
Rabbit Conjunctival Epithelium Transports Fluid, and P2Y2 Receptor Agonists Stimulate Cl- and Fluid Secretion. Yansui Li, Kunyan Kuang, Benjamin Yerxa, Quan Wen, Heinz Rosskothen, and Jorge Fischbarg. American Journal of Physiology. Cell Physiology. 2001, 281:C595-C602.
Ocular Safety of INS365 Ophthalmic Solution: A P2Y2 Agonist in Healthy Subjects. Mohan V. Mundasad, Gary D. Novack, Victoria E. Allgood, Richard M. Evans, JoAnn C. Gorden, and Benjamin R. Yerxa. Journal of Ocular Pharmacology and Therapeutics. 2001, 17:173-179.
NEI Dry Eye Initiative. Workshop I - April 28, 2001. Brief summary notes.
Purine and Pyrimidine (P2) Receptors as Drug Targets. Kenneth A. Jacobson, Michael F. Jarvis, and Michael Wiliams. Journal of Medicinal Chemistry. 2002, 45:4057-4093.
Pharmacology of INS37217 [P1-(uridine 5')-P4- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y2 receptor agonist for the treatment of cystic fibrosis. B.R. Yerxa, J.R. Sabater, C.W. Davis, M.J. Stutts, M. Lang-Furr, M. Picher, A.C. Jones, M. Cowlen, R. Dougherty, J. Boyer, W.M. Abraham, and R.C. Boucher. The Journal of Pharmacology and Experiemntal Therapeutics. 2002, 302:871-880.
Ocular Manifestations of Autoimmune Disease. Sayjal Patel, Diane Lundy. American Family Physician. 2002, 66:991-998.
Challenges and Pitfalls in Clinical Trials of Treatments for Dry Eye. Gary Foulks. The Ocular Surface. 2003, 1:20-30.
Abstracts
A double-masked, randomized, placebo-controlled, dose-escalating study of a single intravitreal injection of INS37217 in subjects with retinal detachment. PE Tornambe, GM Fox, LS Poliner, BJ King, RS Whitsell, LM LaVange, DJ Kellerman. ARVO 2003 ABSTRACT.
Expression of regulator of G-protein signaling 11 (RGS11) in rat and monkey photoreceptors and RPE. LM Gomez, DP Siderovski, WM Peterson. ARVO 2003 ABSTRACT.
Double masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye. J.Tauber, W.F. Davitt, J.E. Bokosky, K.K. Nichols, M.C. Mills-Wilson, A.E. Schaberg, B.R. Yerxa, L.M. LaVange, S.J. Kenny, D.J. Kellerman. ARVO 2003 ABSTRACT.
diquafosol tetrasodium (INS365) ophthalmic solution is not absorbed systemically in patients with dry eye. D.J. Kellerman, K.N. Sall, J.E. Bokosky, M.C. Mills-Wilson, R.S. Whitsell, B.D. Kaufman, B.R. Yerxa. ARVO 2003 ABSTRACT.
Effect of 5-MCA-NAT, a putative melatonin mt3 receptor agonist, on intraocular pressure (IOP) in glaucomatous monkey eyes. J.B. Serle, R-F.Wang, W.M. Peterson, R.Plourde, B.R. Yerxa, S.M. Podos. ARVO 2003 ABSTRACT.
Effect of the P2Y14 receptor agonist, UDP-glucose, on intraocular pressure (IOP) in glaucomatous monkey eyes. S.M. Podos, R-F.Wang, J.L. Boyer, B.R. Yerxa, J.B. Serle. ARVO 2003 ABSTRACT.
Ocular safety in INS365 ophthalmic solution, a P2Y2 agonist, in patients with mild to moderate dry eye disease. Benjamin R. Yerxa, Mohan Mundasad, Robin N. Sylvester, JoAnn C. Gordon, Mark Cooper, and Donald J. Kellerman. Lacrimal Gland, Tear Film & Dry Eye Syndromes: Basic Science and Clinical Relevance 2000 ABSTRACT.
Phase 2 dose ranging efficacy trial of INS365 ophthalmic solution, a P2Y2 agonist, in patients with dry eye. G Foulks, K. Sall, ME Greenberg, J Tauber, P Donshik, G Berdy, R Sylvester B Yerxa, S Crockett, D Kellerman. ARVO 2001 ABSTRACT.
Poster Handouts
Nucleotides and dinucleotides increase re-epithelialisation in rabbit corneal wounds. A. Peral, A. Bautista, G. Carracedo, B. Yerxa, J. Pintor. ARVO. 2002.
Effects of P2Y2 agonists on lipid secretion by cultures rabbit meibocytes. Y. Li, K. Kuang, B. Yerxa, J. Fischbarg. ARVO. 2002.
Presenting symptoms from diary cards for Dry Eye clinical trial subjects. P. Donshik, K. Sall, L. Cacioppo, A. Mayhew, R. Crockett, R. Whitsell, B. Yerxa, D. Kellerman. ARVO. 2002.
Endogenous expression of P2Y1 receptors in 1321N1 human astrocytoma cells. C. Redick, A. Jones, V. Zhang, K. Brubaker, R. Patel, W. Peterson, J. Boyer. Experimental Biology. 2002.
Cellular expression of P2Y2 receptor mRNA as visualized by in situ hybridization in rabbit and monkey. B. Yerxa, V. Zhang, L. Sheridan, C. Moyer, W. Peterson, M. Cowlen. European Association for Vision and Eye Research. 2001.
A single inhaled dose of INS316 enhances sputum quality for the diagnosis of lung cancer. D. Jabalons, D. Everett, G. David, R. Michels, M. Klein, P. Edgar, F. Johnson. European Respiratory Society Annual Congress. 2001.
INS37217, a novel P2Y2 receptor agonist, being developed for the treatment of Cystic Fibrosis: results from Initial Phase 1 Study in normal volunteers. D. Mathews, D. Kellerman, J. Gordon, F. Johnson, R. Evans. European Cystic Fibrosis Society. 2001.
Ecto-metablosim and transport efficiency of P2Y receptor agonists by rabbit ocular surface epitheal cells. B. Yerxa, H. Gukasyan, W. Pendergast, V. Lee. ARVO. 2001.
Metabolism, ocular distribution and ERG effects of INS37217, a novel P2Y2 receptor agonist, for the treatment of retinal detachment. W. Peterson, A. Venturini, M. Cowlen, M. Vezina, G. Piccirilli. ARVO. 2001.
Effects of diadenosine polyphosphates on tear secretion in New Zealand and white rabbits. J. Pintor, A. Peral, C. Hoyle, C. Redick, J. Douglass, I. Sims, B. Yerxa. ARVO. 2001.

 

 

 

 

Page last updated: 8-Sep-2006